Objective: To analyze the clinical characteristics of cardiovascular adverse drug reactions induced by azithromycin injection in children

so as to provide reference for clinical rational drug use. Methods: From Jan. 2013 to Jul. 2021

113 children with cardiovascular adverse drug reactions induced by azithromycin injection were screened out from the adverse drug reaction monitoring platform of Ezhou Central Hospital

Huangshi Central Hospital and the Fifth Hospital of Huangshi. The age

gender

occurrence time of adverse drug reactions

clinical manifestations and outcomes of the children were retrospectively analyzed. Results: Among 113 cases of cardiovascular adverse drug reactions induced by azithromycin injection

83 cases (73. 45%) were mild adverse drug reactions and 30 cases (26. 55%) were moderate adverse drug reactions. The male to female ratio was 1. 35 ∶ 1

and 69 patients (61. 06%) aged ≤3 years. The solvent was normal saline in 71 cases ( 62. 83%) and 5% glucose injection in 42 cases ( 37. 17%). The infusion concentration was 2 mg / mL in 75 cases (66. 37%) and 1 mg / mL in 38 cases (33. 63%). Totally 53 cases (46. 90%) were treated with traditional Chinese medicine injection

33 cases (29. 20%) received theophylline drugs

and 30 cases ( 26. 55%) were given nonsteroidal anti-inflammatory drugs. The clinical manifestations were prolonged Q-T interval in 80 cases (70. 80%) and arrhythmia in 22 cases (19. 47%). The occurrence time of 42 cases (37. 17%) was mainly from 1 h to 1 d

and 25 cases (22. 12%) was from 1 to 3 d. All patients were relieved after drug withdrawal or symptomatic treatment. Conclusion: Prolonged Q-T interval is the most common cause of cardiovascular adverse drug reactions induced by azithromycin injection in children

mostly in children with age ≤3 years and administration time ≤3 d

with normal saline as the solvent and infusion concentration of 2 mg / mL.